Remdesivir
Announcement ID: #231231
Published on 05-13-2021
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Description
CAS No.:1809249-37-3Molecular Formula:C27H35N6O8P
Formula Weight:602.6
Purity:≧98.6%
Storage:-20°C
Stability:≧2 years
Remdesivir is a prodrug form of the antiviral nucleoside analog GS-441524.Which is upon entry into cells, remdesivir is metabolized into a nucleoside monophosphate form, which is further metabolized to an active nucleoside triphosphate that induces RNA chain termination and inhibits viral polymerases.3 Remdesivir reduces viral titers in primary human airway epithelial (HAE) cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV) or severe acute respiratory syndrome CoV (SARS-CoV; EC50s = 0.074 and 0.069 µM, respectively).
It reduces infectious virus production in SARS-CoV-2-infected HAE cells (EC50 = 10 nM).4 In vivo, remdesivir (25 and 50 mg/kg) red